Favourable drug-lead pharmacokinetic features for designing gallic acid-standardized Syzygium polyanthum aqueous extract-based product

In this study, Syzygium polyanthum was standardized against gallic acid (GA), and a complete pharmacokinetic test conducted using in vitro vivo models phytochemical. High-performance liquid chromatography showed that GA is major phytochemical aqueous extract of S. polyanthum. It exhibited low equilibrium solubility physiochemical stability at pH 2.0 7.4, but it deteriorated rapidly 9.2. permeability toward Caco-2 intestinal absorption with eight times slower oral than intravenous administration. unstable mouse, rat, dog plasma sera half-lives (t1/2) 60, 53, 56 min, respectively, relatively stable human serum (t1/2 = 185 min). Approximately 5.6% (10 µM) bound to the proteins. dog, microsomal extracts intrinsic clearance values 72, 68, 6, 22 µL/min/mg, respectively. selectively inhibited or stimulated activity tested CYP450 enzymes. The bioavailability 54%, short elimination half-life high volume distribution. Thus, mention features must be considered during development GA-based products yield optimum dosage pharmacological effect.